Changes in the transcriptome of circulating neutrophils and skeletal muscle in response to endurance exercise

ABSTRACT: Analysis of the changes in the transcriptome of circulating neutrophils and skeletal muscle from standardized resting conditions (baseline; pre-EXTRI) to 3, 48 and 96 hours after an experimental exercise trial (EXTRI; 1 hour of cycling followed by 1 hours of running) in 8 healthy, endurance-trained, male subjects. It was hypothesized that the time-course dependent transcriptomic changes would reflect the molecular and signalling mechanisms by which neutrophils regulate and counter-regulate inflammation, and by which skeletal muscle responds, regenerates, and phenotypically adapts to intense, prolonged exercise involving muscle damage. Results provide an important insight in the signalling pathways underlying the transcriptional activation and priming of circulatory neutrophils in response

ORGANISM(S): Homo sapiens

SUBMITTER: Oliver Neubauer 

PROVIDER: E-GEOD-43856 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress