CD8 T cells induce perforin-dependent pathology in Leishmania braziliensis infection

ABSTRACT: The mechanisms that mediate immunopathologic responses in infectious diseases are often less well understood than how the pathogens are controlled. Here, we have investigated what causes increased pathology following infection with the protozoan parasite, Leishmania braziliensis. We focused on CD8 T cells since their presence in leishmanial lesions has been correlated with increased disease. By adoptively transferring CD8 T cells to L. braziliensis infected RAG mice, we found that unregulated CD8 T cells promote severe pathology at the infection site, as well as the development of metastatic lesions in other skin sites. In mice with severe pathology, we visualized CD8 T cells degranulating and lysing L. braziliensis infected cells, and in parallel studies with L. braziliensis patients

ORGANISM(S): Homo sapiens

SUBMITTER: daniel beiting 

PROVIDER: E-GEOD-43880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress