Transcription profiling of mouse model of amyotrophic lateral sclerosis (ALS) vs. wild type

ABSTRACT: mRNA expression in the spinal cords of the G93A-SOD1 familial ALS transgenic mouse model was compared to that in nontransgenic (Normal mouse) and transgenic mice expressing wild-type (WT)SOD1. Gene Ontology (GO)analysis was used to characterize differences in expression between G93A-SOD1 mouse and nontransgenic mouse spinal cord. Changes in multiple GO categories were found. Many of these were associated with subsystems involving cell-cell communication and intracellular signal transduction. Expression profiles of mice expressing WT-SOD1 did not differ from nontransgenic mice. In contrast, protein profiling using proteomics technology indicated changes in mitochondrial protein expression in the G93A-SOD1 mouse spinal cord that were not found in the mRNA expression analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Lukas 

PROVIDER: E-GEOD-4390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress