Identification of p130Cas/ErbB2 dependent invasive signatures in transformed mammary epithelial cells.

ABSTRACT: Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is over-expressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas over-expression synergizes with ErbB2 in mammary cell transformation and promotes ErbB2-dependent invasion in three-dimensional (3D) cultures of human mammary epithelial cells. Here, by comparing coding and non-coding gene expression profiling, we define the invasive signatures associated with concomitant p130Cas over-expression and ErbB2 activation in 3D cultures of mammary epithelial cells. Specifically, we have found that genes involved in amminoacids synthesis (CBS and PHGDH), cell motili

ORGANISM(S): Homo sapiens

SUBMITTER: antonio lembo 

PROVIDER: E-GEOD-43907 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress