Prominin 1/CD133 Endothelium Sustains Growth of Proneural Glioma

ABSTRACT: As many other tumors, a subset of gliobastoma is thought to be maintained by a restricted population of cancer cells, stem-like cells that express CD133 transmembrane protein. Expression levels of CD133 gene has been linked to a poor prognostic molecular subgroup and is not overexpressed by the PDGF-driven proneural group. Thus, the significance of CD133+ cells for gliomagenesis of the proneural group is undetermined. In addition, the role of the CD133 protein remains elusive and controversial, which results from the difficult isolation of CD133+ cells that has largely relied on the use of antibodies to ill-defined glycosylated epitopes of CD133. Here, we used a knockin lacZ reporter mouse, Prom1lacZ/+, to track Prom1+ cells in the brain and found that Prom1 (prominin1, murine CD133 homolo

ORGANISM(S): Mus musculus

SUBMITTER: Adilia Hormigo 

PROVIDER: E-GEOD-43931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress