Modulator of Apoptosis 1 (MOAP-1) is a highly regulated tumor suppressor protein

ABSTRACT: Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in both the intrinsic and extrinsic modes of cell death or apoptosis. It is an integral partner to the tumor suppressor Ras association domain family 1A (RASSF1A) and functions to activate the Bcl-2 family pro-apoptotic protein Bax. Although RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a tumor suppressor is yet to be determined. In this study, we present several lines of evidence from cancer databases, immnoblotting of cancer cells, proliferation and xenograft assays to demonstrate the role of MOAP-1 as a tumor suppressor. MOAP-1 overexpressed tumors display upregulation of multiple genes including several pro-apoptotic members that may influence the role of MOAP-1 in cell

ORGANISM(S): Homo sapiens

SUBMITTER: Kathryn Graham 

PROVIDER: E-GEOD-43990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress