Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE4093: Resveratrol treatment of daf-16 mutant C. elegans GSE4094: N2 worms treated with Resveratrol GSE4095: Sir-2.1 low copy transgenic Abstract: C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrates the transcriptional induction of a family of genes encoding prion-like glutamine/asparagine-rich proteins involved in endoplasmic reticulum (ER) stress response to unfolded proteins. RNA interference of abu-11, a member of this ER stress gene family, abolishes resveratrol-mediated life span extension, and overexpression of abu-11 extends the life span of transgenic animals. Furthermore, SIR-2.1 normally represses transcription of abu-11 and other ER stress gene family members, indicating that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes. Our findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span. Refer to individual Series

ORGANISM(S): Caenorhabditis elegans

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PROVIDER: E-GEOD-4402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

Viswanathan Mohan M Kim Stuart K SK Berdichevsky Ala A Guarente Leonard L

Developmental cell 20051101 5

C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrates the transcriptional induction of a family of genes encoding prion-like glutamine/aspar ...[more]

PMID: 16256736

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Dataset Information

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

Publications

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

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