Inferring the in vivo cellular program of developing bovine muscle from expression data

ABSTRACT: We outline an in vivo cellular program of bovine longissimus muscle development inferred from expression data from 60 days post conception to 3 months postnatal. Analytic challenges included changes in cellular composition, ambiguous ‘diagnostic’ markers of cell type and contrasts between cattle human and mouse myogenesis. Nevertheless, the expression profiles of the myosin isoforms support slow and fast muscle fibres emanating from primary and secondary myogenesis respectively, while expression of the prenatal myosin subunits is down regulated prior to birth. Of the canonical pro-myogenic Transcription Factors (TF), MYF6 and MYF5 are negatively co-expressed, with MYF6 displaying higher expression in the post-natal samples and MYF5, MYOG, HES6 and PAX7 displaying higher expression in early

ORGANISM(S): Bos taurus

SUBMITTER: Nicholas Hudson 

PROVIDER: E-GEOD-44030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress