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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Liver X Receptors play an antitumoral role in the intestine

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Moschetta

PROVIDER: E-GEOD-44073 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.

Lo Sasso Giuseppe G Bovenga Fabiola F Murzilli Stefania S Salvatore Lorena L Di Tullio Giuseppe G Martelli Nicola N D'Orazio Andria A Rainaldi Stefania S Vacca Michele M Mangia Anita A Palasciano Giuseppe G Moschetta Antonio A

Gastroenterology 20130216 7

<h4>Background & aims</h4>Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated whether expression of activated LXR protects against intestinal tumorigenesis in mice.<h4>Methods</h4>We analyzed the development of colon cancer in mice that express a con ...[more]

PMID: 23419360

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