Hypothalamic gene expression of appetite regulators in a cancer-cachectic mouse model
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Guido Hooiveld
PROVIDER: E-GEOD-44082 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hypothalamic food intake regulation in a cancer-cachectic mouse model.
Dwarkasing Jvalini T JT van Dijk Miriam M Dijk Francina J FJ Boekschoten Mark V MV Faber Joyce J Argilès Josep M JM Laviano Alessandro A Müller Michael M Witkamp Renger F RF van Norren Klaske K
Journal of cachexia, sarcopenia and muscle 20131113 2
<h4>Background</h4>Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still a ...[more]
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