Platelet micro-RNA expression in type 2 diabetes mellitus

ABSTRACT: Results Platelets in non-diabetic patients demonstrated miRNA expression profiles comparable to previously published data. The miRNA expression profiles of platelets in diabetics were similar. Statistical analysis unveiled only three miRNAs (miR-377-5p, miR-628-3p, miR-3137) with high reselection probabilities in resampling techniques, corresponding to signatures with only modest discriminatory performance. Functional annotation of predicted targets for these miRNAs pointed towards an influence of diabetes mellitus on mRNA processing. Conclusions/interpretation We did not find any major differences in platelet miRNA profiles between diabetics and non-diabetics. Minor differences pertained to miRNAs associated with mRNA processing. Thus, previously described differences in plasma miRNAs b

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Nuehrenberg 

PROVIDER: E-GEOD-44093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress