COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.

ABSTRACT: Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovarian cancer. Microarray analysis suggested that COL11A1 is a disease progression-associated gene that is linked to ovarian cancer recurrence and poor survival. Whole tumor gene expression profiling was conducted on tissue samples from 60 ovarian cancer patients, and characteristics and clinico-pathological features of the patients are provided. We used several steps to analyze the expression profiles of the samples to identify the genes whose expression values correlate with su

ORGANISM(S): Homo sapiens

SUBMITTER: Tzu-Hao Chang 

PROVIDER: E-GEOD-44104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress