MiRNA/gene profiling unveils early molecular changes and NRF2 activation in a rat model recapitulating human HCC

ABSTRACT: Studies on gene and/or microRNA (miRNA) dysregulation in the early stages of hepatocarcinogenesis are hampered by the difficulty of diagnosing early lesions in humans. Experimental models recapitulating human hepatocellular carcinoma (HCC) are then entailed to perform this analysis. We performed miRNA and gene expression profiling to characterize the molecular events involved in the multistep process of hepatocarcinogenesis in the Resistant-Hepatocyte rat model. A high percentage of dysregulated miRNAs/genes in HCC were similarly altered in early preneoplastic lesions positive for the stem/progenitor cell marker cytokeratin-19, indicating that several HCC-associated alterations occur from the very beginning of the carcinogenic process. Our analysis also identified miRNA/gene-target network

ORGANISM(S): Rattus norvegicus

SUBMITTER: Davide Cora' 

PROVIDER: E-GEOD-44106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress