Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish

ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. These multi-ring chemicals differentially activate the Aryl Hydrocarbon Receptor (AHR) in a structurally-dependent manner, and induce toxicity via both AHR-dependent and -independent mechanisms. PAH exposure is known to induce developmental malformations in zebrafish embryos, and recent studies have shown cardiac toxicity induced by compounds with low AHR affinity. Unraveling the potentially diverse molecular mechanisms of PAH toxicity is essential for understanding the hazard posed by complex PAH mixtures present in the environment. We analyzed transcriptional responses to PAH exposure in zebrafish embryos exposed to benz(a)anthracene (BAA), dibenzothiophe

ORGANISM(S): Danio rerio

SUBMITTER: Susan Tilton 

PROVIDER: E-GEOD-44130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress