Development of gene expression signatures for senecionine exposure

ABSTRACT: Senecionine is among the most well-studied pyrrolizidine alkaloids, which have caused intense and lasting attention for their significant hepatotoxicity. To develop gene expression approach to senecionine exposure, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to be biomarkers after senecionine exposure. Rat liver tissues after 36 h of senecionine treatment (i.g., 35 mg/kg body weight) were collected and analyzed comparing with control samples (i.g., sodium chloride solution). Differentially expressed genes were identified through Fold-change filtering and subjected to GO term using gene ontology project (http://www.geneontology.org/) to uncover the co-expression network on the basis of biological process and mole

ORGANISM(S): Rattus norvegicus

SUBMITTER: aizhen xiong 

PROVIDER: E-GEOD-44144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress