Comparison of transcriptional profiles of PBMCs from HIV-infected rapid progressors and chronic progressors

ABSTRACT: A significant percentage of HIV-infected individuals experience a sharp decline in CD4+ T cell counts and progress to AIDS quickly after primary infection. Identification of biomarkers distinguishing rapid progressors (RPs) versus chronic progressors (CPs) is critical for early clinical intervention and could provide novel strategies to facilitate vaccine design and immune therapy. mRNA and miRNA expression profiles in the peripheral blood mononuclear cells (PBMCs) of RPs and CPs were investigated at 111±22 days (Mean±SD) of HIV infection. The association of mRNA and miRNA expression with disease progression was examined by receiver operating characteristic analysis and Kaplan-Meier survival analysis. Pathway enrichment analysis showed that genes with deregulated expression in RPs are pr

ORGANISM(S): Homo sapiens

SUBMITTER: zining zhang 

PROVIDER: E-GEOD-44216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress