Long-range bidirectional transcription is a general feature of developmental gene promoters in mammals (RNA-Seq 1)

ABSTRACT: Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the RNA degradation machinery is inhibited. Here, we used RNA-seq with very high sequencing depth to characterize strand specific transcripts from primary mouse tissues. We found that a substantial fraction of gene promoters sustain expression of long non-coding antisense transcripts. These transcripts have an average size of 6 kb, have features of mature transcripts, but remain associated with the chromatin. We named this new class of non-coding RNAs Long Upstream Antisense Transcripts (LUAT). Strik

ORGANISM(S): Mus musculus

SUBMITTER: Aurelie Bergon 

PROVIDER: E-GEOD-44232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress