Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kevin Becker
PROVIDER: E-GEOD-44240 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tripathi Vidisha V Shen Zhen Z Chakraborty Arindam A Giri Sumanprava S Freier Susan M SM Wu Xiaolin X Zhang Yongqing Y Gorospe Myriam M Prasanth Supriya G SG Lal Ashish A Prasanth Kannanganattu V KV
PLoS genetics 20130321 3
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analyses in normal human diploid fibroblasts reveal that MALAT1 modulates the expression of cell cycle genes and is required for G1/S and mitotic progression. Depletion of MALAT1 leads to activation of p53 ...[more]