Transcriptomic effects of endocrine disruptors in zebrafish embryos

ABSTRACT: The identification of endocrine disruptive properties of chemicals certain to enter the aquatic environment relies on toxicity tests with fish, assessing adverse effects on reproduction and sexual development. The demand for quick, reliable endocrine disruption (ED) assays favored the use of fish embryos as alternative test organisms. We investigated the application of a transcriptomics-based assay for estrogenic and anti-androgenic chemicals with zebrafish embryos. Two reference compounds, 17a-ethinylestradiol and flutamide, were tested to evaluate the effects on development and the transcriptome after 48h-exposures. Comparison of the transcriptome response with other estrogenic and anti-androgenic compounds (genistein, bisphenol A, methylparaben, linuron, prochloraz, propanil) showed com

ORGANISM(S): Danio rerio

SUBMITTER: Viktoria Schiller 

PROVIDER: E-GEOD-44263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress