Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner

ABSTRACT: WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors with highly restricted expression in the adult where Sost was assumed 'osteocyte-' and Sostdc1 'kidney-' specific. Here we show that these two proteins emerged throgh ancestral genome duplication and their expression patterns have diverged to span complimentary domains in most organ systems including musculoskeletal, cardiovascular, nervous, digestive, reproductive and respiratory. In the developing limb, Sost and Sostdc1 display dynamic expression patterns with Sost being restricted to the dist

ORGANISM(S): Mus musculus

SUBMITTER: Gabriela Loots 

PROVIDER: E-GEOD-44325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress