Next generation sequencing in ZS rats

ABSTRACT: Next generation sequencing in a rat model of diabetic nephropathy was employed to study in depth the pathogenic alterations involved in progressive diabetic kidney damage. We employed the obese, diabetic ZS rat, a model that develops renal failure and fibrosis, the hallmarks of human disease. We then used RNA-seq to examine in a comprehensive manner the combined effects of renal cells and infiltrating inflammatory cells acting as a pathophysiological unit. 12 samples (4 independent samples for each of 3 groups, 1 control group)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Hai Lin 

PROVIDER: E-GEOD-44375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress