Stress-response pathways are altered in the hippocampus of chronic alcoholics

ABSTRACT: Comparison of gene expression in post-mortem hippocampus from 20 alcoholics and 19 controls. The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis. Examining gene expression in post mortem hippocampal tissue from 20 alcoholics and 19 controls allowed us to detect differentially expressed genes that may play a role in the risk for alcoholism or whose expression is modified by chronic consumption of alcohol. We identified 639 named genes whose expression significantly differed between alcoholics and controls at a False Discovery Rate (FDR) ? 0.20; 52% of these genes differed by at least 1.2-fold. Differentially expressed genes

ORGANISM(S): Homo sapiens

SUBMITTER: Jeanette McClintick 

PROVIDER: E-GEOD-44456 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress