Dataset Information
Hedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Keilty
PROVIDER: E-GEOD-44581 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
Molecular cancer therapeutics 20140314 5
Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironment. Chondrosarcoma is a malignant tumor of cartilage in which there is ligand-dependent activation of Hh signaling. IPI-926 is a potent, orally delivered small molecule that inhibits Hh pathway signaling by binding to Smoothened (SMO). Here, the impa ...[more]
