Hedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth

ABSTRACT: Mice bearing primary human chondrosarcoma xenografts were treated with IPI 926, and mRNA levels of known Hh pathway genes and endpoint tumor volumes were measured. Gene expression profiling of IPI-926 treated tumors was conducted to identify potential novel Hh target genes. 4 Control treated and 4 IPI-926 treated NSG Mice. Primary tumor was obtained from a single chondrosarcoma patient.

ORGANISM(S): Homo sapiens

SUBMITTER: John Keilty 

PROVIDER: E-GEOD-44581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress