VGLL4 is a novel regulator of survival in human embryonic stem cells

ABSTRACT: Human embryonic stem cells (hESCs) are maintained in a self-renewing state by an interconnected network of mechanisms that sustain pluripotency, promote proliferation and survival, and prevent differentiation. We sought to find novel genes that could contribute to one or more of these processes by using a gain-of-function screen of a large collection of human open reading frames. We identified Vestigial-like 4 (VGLL4), a co-transcriptional regulator with no previously described function in hESCs, as a positive regulator of survival in hESCs. Specifically, VGLL4 overexpression in hESCs significantly decreases cell death in response to dissociation stress. Additionally, VGLL4 overexpression enhances hESC colony formation from single cells. These effects may be attributable, in part, to a dec

ORGANISM(S): Homo sapiens

SUBMITTER: Adriana Tajonar 

PROVIDER: E-GEOD-44590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress