Molecular Evidence for a Dimensional Basis of Depression

ABSTRACT: Here we identified a set of genes with frequent expression changes in the postmortem brain of MDD subjectsand show that this gene set is genetically related to brain and organ illnesses frequently associated with MDD. Specifically, we performed a meta-analysis of eight gene array studies in three corticolimbic brain regions and identified ~450 genes frequentlyderegulated in MDD (n=103 subjects, 50.5%MDD). These “MetaA-MDD” genes includepreviously-implicated neuroplasticity- and stress-related genes (CRH, BDNF, VGF), encompass multiple synaptic and signaling pathways, and suggests complex changes in cell structure and function. MetaA-MDD genes display low connectivity andhubnessin coexpression networks andare evenly distributed throughout the genome. However, MetaA-MDD genesare signific

ORGANISM(S): Homo sapiens

SUBMITTER: YING DING 

PROVIDER: E-GEOD-44593 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress