Transcription profiling of mouse renal epithelial cells from inv mutant animals

ABSTRACT: Nephronophthisis (NPHP) is a group of progressive renal disorders characterized by a variable number of cysts associated with cortical tubular atrophy. Recently, mutations in INV have been identified to be responsible for NPHP2. The inv/inv,inv-deltaC::GFP mouse that was created by introduction of inv gene lacking the C-terminus (inv-deltaC) into inv/inv mice develops multiple renal cysts without situs abnormality. Renal cyst progression was dependent on expression level of inv-deltaC transgene, suggesting that inv protein functions in a dose-dependent manner. Cell proliferation and apoptosis were increased in the inv-deltaC cystic kidneys. We searched up- and down-regulated genes during cyst development and progression using cDNA microarray. See appended table for comparison analysis o

ORGANISM(S): Mus musculus

SUBMITTER: Noriyuki Sugiyama 

PROVIDER: E-GEOD-4462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress