Activation and repression by oncogenic Myc shapes tumour-specific gene expression profiles

ABSTRACT: In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downregulated genes that have significant prognostic value. To understand this discrepancy, we studied the consequences of inducible expression and depletion of Myc in human cells and murine tumour models. Changes in Myc levels activate and repress specific sets of direct target genes that are characteristic of Myc-transformed tumour cells. Three factors account for this specificity: First, the magnitude of response parallels the change in occupancy by Myc at each promoter. Functionally distinct classe

ORGANISM(S): Homo sapiens

SUBMITTER: Susanne Walz 

PROVIDER: E-GEOD-44672 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress