The ParS/ParR regulon in Pseudomonas aeruginosa PAO1

ABSTRACT: The ParS/ParR two component regulatory system plays important roles for multidrug resistance in Pseudomonas aeruginosa. In this study we report RNA-seq analyses of the transcriptomes of P. aeruginosa PAO1 wild type and par mutants growing in a minimal medium containing 2% casamino acids. This has allowed the quantification of PAO1 transcriptome, and further defines the regulon that is dependent on the ParS/ParR system for expression. Our RNA-seq analysis produced the first estimates of absolute transcript abundance for the 5570 coding genes in P. aeruginosa PAO1. Comparative transcriptomics of P. aeruginosa PAO1 and par mutants identified a total of 464 genes regulated by ParS and ParR. Results also showed that mutations in the parS/parR system abolished the expression of the mexEF-oprN op

ORGANISM(S): Pseudomonas aeruginosa PAO1

SUBMITTER: Dongping Wang 

PROVIDER: E-GEOD-44681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress