Multiple roles for Grainyheadlike transcription factors in the establishment and maintenance of human mucociliary airway epithelium

ABSTRACT: The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evidence that transcription factors of the evolutionarily conserved grainyheadlike (GRHL) family play key roles in co-ordinating the expression of numerous proteins required for epithelial morphogenesis, differentiation, remodeling and repair. However, little is known about their function in the adult lung. Here, we focus on the role of GRHL2 in primary human bronchial epithelial (HBE) cells, using either shRNA or a dominant negative protein (DN-GRHL2) to inhibit its function. We follow changes in e

ORGANISM(S): Homo sapiens

SUBMITTER: Timothy Reddy 

PROVIDER: E-GEOD-44718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress