Genome-wide analysis reveals DNA methylation markers that varies with both age and obesity

ABSTRACT: Background: The obesity epidemic and the aging population of many western countries together with their associated diseases are major challenges for the healthcare. As obesity is a risk factor for many age related diseases, such as cancer, it is of importance to understand their interaction and the underlying molecular mechanisms. Lately, epigenetic programming in the form of DNA methylation and have been recognized for its importance in aging, obesity and several diseases. Method: Herein, the methylation level was determined for around 27000 CpG-islands in 46 DNA samples from adult peripheral blood with microarrays. The dependence for each CpG island with age, obesity and their interaction was ascertained with a general linear model. Results: The methylation level of more than 100 gen

ORGANISM(S): Homo sapiens

SUBMITTER: Markus Sällman Almén 

PROVIDER: E-GEOD-44763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress