The expanded regulatory T cell population in chronic filarial infection is highly heterogeneous, activated and suppresses dendritic cell function indirectly through effector T cells.

ABSTRACT: Natural regulatory T cells (nTregs) are known to increase during chronic infection or at the site tumor, though the exact mechanisms that contribute to their accumulation and mode of action remain unclear. We used flow cytometry and microarray analyses to delineate the phenotype of nTregs and their role in modulating T cell and antigen presenting cell (APC) function in the setting of chronic infection. Using cells from 18 filaria-infected (Fil+) and 19 filaria-uninfected (Fil-) subjects, we found that the frequencies of nTreg expressing CTLA-4, GITR, LAG-3, and IL-10 were significantly higher in Fil+ compared with Fil- subjects. Microarray analysis revealed that, compared with those from Fil-, nTreg populations in Fil+ subjects were more heterogeneous and had higher expression of IL-10, CC

ORGANISM(S): Homo sapiens

SUBMITTER: Dan Sturdevant 

PROVIDER: E-GEOD-44767 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress