Study of the association of DNAhsp65 immunotherapy and conventional drugs in experimental tuberculosis

ABSTRACT: Despite substantial investments, tuberculosis remains one of the biggest challenges in public health. DNA-immunotherapy is increasingly being suggested as a possibility to assist conventional treatment of tuberculosis. This strategy could allow treatment to be more efficient, faster and with advantages and modulate the host immune response, as demonstrated by our group with DNAhsp65 vaccine (Silva, Bonato et al., Gene Therapy, 2005). Based on this evidences, we performed a microarray assay to stydy the functional effects of DNAhsp65 immunotherapy associated with conventional chemotherapy in murine experimental tuberculosis. Briefly, we used a murine model of tuberculosis treatment compost by DNAhsp65 vaccine, or rifampicin and isoniazid or both therapies combined and performed a comprehens

ORGANISM(S): Mus musculus

SUBMITTER: Rodrigo Rodrigues 

PROVIDER: E-GEOD-44825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress