Genomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington's disease
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Luis Valor
PROVIDER: E-GEOD-44855 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease.
Valor Luis M LM Guiretti Deisy D Lopez-Atalaya Jose P JP Barco Angel A
The Journal of neuroscience : the official journal of the Society for Neuroscience 20130601 25
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcriptional and acetylation alterations at the whole-genome level, remain unknown. The new techniques for the mapping of histone post-translational modifications at genomic scale enable such global analyse ...[more]
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