Maternal western diet primes susceptibility to hepatic inflamation in adult male mouse offspring

ABSTRACT: Background & Aims: The influences of the maternal diet during gestation has been suggested to be involved in the development of different aspects of the metabolic syndrome. In our mouse model we characterised the role of maternal western diet in the development of non-alcoholic fatty liver disease (NAFLD) in the offspring. Methods: Female mice were fed either a western (W) or low-fat control (L) semi-synthetic diet before and during gestation and lactation. At weaning, male offspring were assigned either the W or the L diet, generating four experimental groups: WW, WL, LW and LL offspring. Biochemical, histological and epigenetic indicators were investigated at 29 weeks of age. Results: Male offspring exposed to prenatal western style diet and to a post-weaning W diet (WW) showed hepatome

ORGANISM(S): Mus musculus

SUBMITTER: vincent bloks 

PROVIDER: E-GEOD-44901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress