Genome-wide mRNA expression analysis of the impact of electron radiation on Daltons lymphoma ascites cells in vivo

ABSTRACT: The gene expression changes induced upon electron radiation in cancer cells is largely unexplored. We investigated the effect of electron radiation generated from 8 MeV Microtron in Daltons lymphoma ascites (DLA) cells bearing mice model. Mice implanted with DLA cells in their peritoneal cavity were exposed to 2 Gy dose of electron radiation. 48 Hours after irradiation, tumor cells were harvested from peritoneal cavity of both treatment-naive and total body irradiated mice. Microarray based genome-wide mRNA profiling approach was used to identify the differentially expressed genes between control and treated groups. 249 genes were found altered in DLA cells upon electron irradiation, of which 176 genes were upregulated and 73 genes were downregulated. The microarray results from this study

ORGANISM(S): Mus musculus

SUBMITTER: Kumaresan Ganesan 

PROVIDER: E-GEOD-44908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress