Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation

ABSTRACT: Adult mouse subventricular zone (SVZ) neural progenitor cells (NPCs) retain the capacity to generate multiple lineages in vitro and in vivo. Thus far, the mechanisms involved in the regulation of these cells have not been well elucidated. We have carried out RNA profiling of adult SVZ cell cultures undergoing differentiation, to identify pathways that regulate progenitor cell proliferation and to define a set of transcripts that can be used as molecular tools in the drug discovery process. We carried out a stepwise stratification of the results to identify transcripts specifically enriched in NPCs and validated some of these using comparative literature analysis, quantitative PCR and immunological techniques. The results show a set of transcription factors, secreted molecules, and plasma

ORGANISM(S): Mus musculus

SUBMITTER: Ignacio Munoz-Sanjuan 

PROVIDER: E-GEOD-4496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress