Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Hui Wang

PROVIDER: E-GEOD-44966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.

Gustafsson Mika M Edström Måns M Gawel Danuta D Nestor Colm E CE Wang Hui H Zhang Huan H Barrenäs Fredrik F Tojo James J Kockum Ingrid I Olsson Tomas T Serra-Musach Jordi J Bonifaci Núria N Pujana Miguel Angel MA Ernerudh Jan J Benson Mikael M

Genome medicine 20140226 2

<h4>Background</h4>Translational research typically aims to identify and functionally validate individual, disease-specific genes. However, reaching this aim is complicated by the involvement of thousands of genes in common diseases, and that many of those genes are pleiotropic, that is, shared by several diseases.<h4>Methods</h4>We integrated genomic meta-analyses with prospective clinical studies to systematically investigate the pathogenic, diagnostic and therapeutic roles of pleiotropic gene ...[more]

PMID: 24571673

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Dataset Information

Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment

Publications

Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.

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