Overexpression of NEK6 Associated with Poor Prognosis of Esophageal Squamous Cell Carcinoma

ABSTRACT: Esophageal squamous cell carcinoma (SCC) is frequently diagnosed at advanced stage and associated with poor prognosis. This study aimed to identify differentially expressed genes for further evaluated as biomarkers for predicting survival of the patients. Five paired of cancerous and normal tissues from esophageal SCC patients were subjected to cDNA microarray analysis and one of these differentially expressed genes, NEK6, was further verified in esophageal SCC tissues. The data showed 444 up-regulated genes and 918 down-regulated genes in tumor tissues (2 folds as a cut-off value). qRT-PCR data showed that 20 of 30 (66.7%) increased levels of NEK6 mRNA in cancerous tissues compared to that of distant normal tissues, while immunohistochemical data showed that 49/94 (52.13%) of the archived

ORGANISM(S): Homo sapiens

SUBMITTER: wang liang 

PROVIDER: E-GEOD-45168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress