Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

ABSTRACT: Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to investigate the transcriptomes of cSCC and actinic keratoses (AK), to elucidate key differences between precursor AK lesions and invasive carcinoma. This study identified 196 genes that are differentially expressed between AK and cSCC, with enrichment for processes including epidermal differentiation, cell migration, cell cycle regulation and metabolism. Gene set enrichment analysis highlighted a key role for the MAPK pathway in the transition from AK to cSCC. Furthermore, the differentiation status

ORGANISM(S): Homo sapiens

SUBMITTER: Sally Lambert 

PROVIDER: E-GEOD-45216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress