Transcription profiling of human Th cells expressing Foxp3 and UBD ectopically
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Robert Geffers
PROVIDER: E-GEOD-4527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells.
Ocklenburg Frank F Moharregh-Khiabani Darius D Geffers Robert R Janke Viktoria V Pfoertner Susanne S Garritsen Henk H Groebe Lothar L Klempnauer Juergen J Dittmar Kurt E J KE Weiss Siegfried S Buer Jan J Probst-Kepper Michael M
Laboratory investigation; a journal of technical methods and pathology 20060515 7
Here, we report the identification of the ubiquitin-like gene UBD as a downstream element of FOXP3 in human activated regulatory CD4(+)CD25(hi) T cells (T(reg)). Retroviral transduction of UBD in human allo-reactive effector CD4(+) T helper (T(h)) cells upregulates CD25 and mediates downregulation of IL4 and IL5 expression similar to overexpression of FOXP3. Moreover, UBD impairs T(h) cell proliferation without upregulation of FOXP3 and impairs calcium mobilization. In the presence of ionomycin, ...[more]
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