DNA copy number profiles of premalignant endobronchial lesions: a validated predictor for endobronchial cancer

ABSTRACT: Individuals who present with premalignant endobronchial lesions are considered at high risk of lung cancer. Nonetheless, premalignant lesions behave erratically and only a minority progresses towards lung cancer. Therefore, biomarkers need to be discovered that can aid in assessing an individual’s risk for subsequent cancer to better tailor treatment choices and avoid unnecessary follow-up procedures. We recently proposed a classifier of DNA copy number alterations (CNAs) at 3p26.3-p11.1, 3q26.2-29, and 6p25.3-24.3 as risk predictor for endobronchial cancer. The current study was set out to validate the classifier among an independent series of premalignant endobronchial lesions with various histological grades. A series of 36 endobronchial premalignant lesions (8 squamous metaplasia, an

ORGANISM(S): Homo sapiens

SUBMITTER: Daoud Sie 

PROVIDER: E-GEOD-45287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress