Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ruth Yu
PROVIDER: E-GEOD-45319 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diabetes 20140410 9
Glycogen and lipids are major storage forms of energy that are tightly regulated by hormones and metabolic signals. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic scaffolding protein PTG/R5. PTG promoter activity was increased and glycogen levels were augmented in mice and cells after activation of the mechanistic target of rapamycin complex 1 (mTORC1) and its downstream target SREBP1. Deletion of the PTG gene in mi ...[more]