Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nathan VanderKraats
PROVIDER: E-GEOD-45335 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vanderkraats Nathan D ND Hiken Jeffrey F JF Decker Keith F KF Edwards John R JR
Nucleic acids research 20130607 14
Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a generally accepted mechanism for silencing expression. While recent technological advances have enabled measurement of DNA methylation and expression changes genome-wide, only modest correlations between differential methylation at gene promoters and expression have been found. We hypothesize that stronger associations are not observed because existing analysis methods oversimplify their representation of the data ...[more]