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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse primary FDC and BMDC

ABSTRACT: expression profiles of FDC and BMDC are compared Experiment Overall Design: expression profiles of FDC and BMDC are compared

ORGANISM(S): Mus musculus

SUBMITTER: Masaki Hikida

PROVIDER: E-GEOD-4535 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Establishment of lymphotoxin beta receptor signaling-dependent cell lines with follicular dendritic cell phenotypes from mouse lymph nodes.

Nishikawa Yumiko Y Hikida Masaki M Magari Masaki M Kanayama Naoki N Mori Masaharu M Kitamura Hiroshi H Kurosaki Tomohiro T Ohmori Hitoshi H

Journal of immunology (Baltimore, Md. : 1950) 20061001 8

Follicular dendritic cells (FDCs) have been shown to play a crucial role in the positive selection of high-affinity B cells that are generated by somatic hypermutation in germinal center (GC). Because of technical difficulties in preparing and maintaining pure FDCs, a role for FDCs in this complicated process has not been fully elucidated. In this study, we established a cell line designated as pFL that retained major FDC phenotypes from a three-dimensional culture of mouse lymph node cells. pFL ...[more]

PMID: 17015706

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