An Integrated Model of the Transcriptome Landscape of HER2-Positive Breast Cancer

ABSTRACT: The goal of our study is to build an integrated transcriptome landscape model for HER2 positive breast tumors and identify the crucial signaling pathways associated with HER2 tumors. Genomic features include, 685 genes that were differentially expressed only in HER2-positive tumors, 102 genes that were alternatively spliced in a pattern that is unique to HER2-positive tumors, and 303 genes that expressed single nucleotide sequence variants (eSNVs) that were unique to HER2-positive tumors. Network analysis was performed to integrate the genomic features into a transcriptome landscape model that identified 12 highly interconnected cellular processes that appear to be critical to the establishment and maintenance of HER2-positive tumors. We observed that integrin signaling was linked to lapat

ORGANISM(S): Homo sapiens

SUBMITTER: Krishna Kalari 

PROVIDER: E-GEOD-45419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress