Transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training

ABSTRACT: We sought to ascertain the time-course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naïve individuals, and determine if the magnitude of any response was associated with exercise induced muscle damage. Sixteen RE naïve males were recruited, 8 underwent 2 sessions of 5x30 maximum, isokinetic knee extensions (180°.s-1) separated by 48 hrs. Muscle biopsies of the vastus lateralis were taken at baseline and 24 hrs after each exercise bout. Eight individuals acted as non-exercise controls with biopsies obtained at the same time intervals. Transcriptional changes were assessed by microarray, and binding of HSP27 and αB-crystallin to insoluble proteins by immunohistochemistry as a measure of muscle damage. In control subje

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Murton 

PROVIDER: E-GEOD-45426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress