Expression data from BRAF-mutant melanoma cell lines

ABSTRACT: Melanoma cell lines were assessed for differences in gene expression patterns between the lines sensitive and resistant to BRAF and MEK inhibitor drugs. 22 BRAF-mutant melanoma cell lines were assessed for response to BRAF and MEK inhibitors in a 3 day drug treatment dose response assay. Based on the IC50, 18 lines were found to be responsive to BRAF or MEK inhibition and 4 were resistant. Normalised gene expression data generated from experimental replicate affymetrix arrays was assessed to identify differential patterns of inherent gene expression between the cell lines grouped as drug-responsive or drug-resistant. This were used to idenify specific candidate genes and pathways associated with inherent BRAF/MEK inhibitor drug resistance in melanoma cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Petranel Ferrao 

PROVIDER: E-GEOD-45558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress