Brain microvessel: Alzheimer disease vs normal

ABSTRACT: The enigma that is Alzheimer's disease (AD) continues to present daunting challenges for effective therapeutic intervention. The lack of disease-modifying therapies may, in part, be attributable to the narrow research focus employed to understand this complex disease. Most studies into disease pathogenesis are based on a priori assumptions about the role of AD lesion-associated proteins such as amyloid-? and tau. However, the complex disease processes at work may not be amenable to single-target therapeutic approaches. Genome-wide expression studies provide an unbiased approach for investigating the pathogenesis of complex diseases like AD. A growing literature suggests a role for cerebrovascular contributions to the pathogenesis of AD. The objective of the current study is to examine huma

ORGANISM(S): Homo sapiens

SUBMITTER: Uzma Qaisar 

PROVIDER: E-GEOD-45596 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress