Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk

ABSTRACT: Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime accumulation of cellular, particularly DNA, damage. However, during middle-age, the incidence begins to decelerate and, for many tumor sites, it actually decreases at sufficiently advanced ages. We investigated if the observed deceleration and potential decrease in incidence could be attributed to a decreased capacity of older hosts to support tumor progression, and whether HZE (high atomic number (Z), high energy (E)) radiation differentially modulates tumor progression in young versus middle-ag

ORGANISM(S): Mus musculus

SUBMITTER: christine briggs 

PROVIDER: E-GEOD-45606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress