MSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIa

ABSTRACT: Recent exon sequencing studies of human tumors have revealed that subunits of mSWI/SNF or BAF complexes are mutated in more than 20% of human malignancies, yet the mechanisms involved in tumor suppression is unclear. BAF chromatin remodeling complexes are polymorphic assemblies that use energy provided by ATP hydrolysis to regulate transcription through the control of chromatin structure and the placement of Polycomb (PcG) across the genome. Several proteins dedicated to this large multi-subunit complex, including SMARCA4 (BRG1) and BAF250A (ARID1A), are mutated at frequencies similar to that of many recognized tumor suppressors. In particular, the core ATPase BRG1 is mutated in 5-10% of childhood medulloblastoma (MB) and greater than 15% of Burkitt's Lymphoma (BL). Here we find a novel fu

ORGANISM(S): Mus musculus

SUBMITTER: Emily Dykhuizen 

PROVIDER: E-GEOD-45625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress